November 2026
2026-11-03 ⚗️ 9 🧬 6 💻 10 🏢 5
Tonight's 30 items run from cereblon glues, HDAC3 PROTACs and covalent DEL hits in medchem to sceptical computational reads on docking reproducibility and virtual-screening hits that fail resynthesis. In industry, uniQure's AMT-130 priority review and the ivonescimab combination race lead.
2026-11-02 ⚗️ 8 🧬 8 💻 9 🏢 2
Today's digest has 27 articles: 8 medchem, 8 pharmacology, 9 computational and 2 industry. Highlights include a first-in-class METTL1 inhibitor in Nature, audits showing leakage can inflate AI ADMET and peptide-prediction claims, and a partial clinical hold on Kite's KITE-753 CAR-T trials.
2026-11-01 ⚗️ 7 🧬 7 💻 1 🏢 6
Today's digest has 21 items: Science Translational Medicine work on Treg-depleting CCR8 engagers and synNotch CAR T, KRAS G12D and KEAP1–NRF2 chemistry, and Q3 reads from Sanofi, Regeneron, AbbVie and Alnylam. Computational coverage is a single toxicity-benchmark preprint.