Binding fluxes add time-resolved insight to rate-constant views of ligand binding
- Binding fluxes, the rates at which receptor states interconvert, are presented as a time-resolved complement to rate constants.
- Simulated data came from Euler-method integration of flux-based equations for increasingly complex binding models.
- The flux view clarified transient binding overshoots and the effect of a closing lid on dissociation; rate constants stayed essential.
💡 Points Based on the abstract
I'd take this as a diagnostic lens, not a new parameter set. Flux plots are handy for explaining why a compound overshoots transiently or why a closing lid slows off-rate, but the evidence here is simulation only. Until someone fits real association/dissociation time courses with it, I'd keep reading kon/koff and residence time first.