PFOS found in human pancreas, disrupts insulin secretion
- In organ donors, PFOS was found in nearly all pancreas samples, far more often than PFHxS or PFOA; mouse data also showed PFOS accumulating in pancreas.
- In cell lines and islets, prolonged high-dose PFOS suppressed insulin secretion, while acute exposure boosted it in mouse and some human islets.
- A GLP-1 receptor antagonist partly blunted the acute surge, and in mice PFOS raised insulin only alongside glucose, so the model chosen shapes the result.
💡 Points
Biphasic data are hard to build on: acute PFOS raised insulin, prolonged high doses suppressed it, and the mouse response needed glucose present. Pancreatic concentrations measured alongside these doses are missing, so the human relevance of the in vitro exposures stays open. The partial GLP-1R antagonist block is a lead worth following, though likely one arm of the mechanism.