Triptonide curbs macrophage glycolysis to ease sepsis-related lung injury
- Triptonide, a diterpenoid from Tripterygium wilfordii, was tested in mouse endotoxemia and caecal ligation and puncture models of sepsis-associated lung injury.
- It limited macrophage pro-inflammatory activation, reduced lung inflammation, oedema and apoptosis, and improved survival.
- Transcriptomic and metabolic analyses showed suppressed aerobic glycolysis in inflammatory macrophages, via the STAT3/HIF-1α axis.
💡 Points Based on the abstract
Triptonide is a notoriously narrow-window Tripterygium compound, so I'd want the therapeutic index before any mechanism claim. Dosing after CLP onset, not just pre-treatment, plus a STAT3 or HIF-1α rescue to prove the axis is causal, would tell me far more. Glycolysis suppression in macrophages also risks blunting host defence against the infection itself.