Review surveys molecular editing strategies for late-stage modification of natural products and existing drug molecules
- This review surveys methods for directly modifying complex molecules, mainly natural products and drug molecules, at a late stage.
- Strategies are grouped into skeletal editing and peripheral editing, each illustrated with recent representative examples.
- Biomimetic, nature-inspired editing gets a brief discussion; the authors aim to guide site-selective diversification of complex scaffolds.
💡 Points Based on the abstract
The real pitch here: once a scaffold is precious and gram-limited, editing the core or periphery of the material in hand beats a 15-step re-synthesis of each analog. I'd still check site selectivity and functional-group tolerance on my actual lead before counting on any of it.
Direct Molecular Editing of Complex Molecules for Drug Discovery ↗